Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep3 | Adrenal cortex (to include Cushing's) | ECE2016

Pro-coagulant imbalance in patients with Cushing disease detected by thrombin generation assay is associated with increased levels of neutrophil extracellular trap-related factors

Verrua Elisa , Sala Elisa , Malchiodi Elena , Ferrante Emanuele , Arnaldi Giorgio , Trementino Laura , Tripodi Armando , Semeraro Fabrizio , Ammollo Concetta T , Colucci Mario , Padovan Lidia , Chantarangkul Veena , Peyvandi Flora , Mantovani Giovanna

Patients with Cushing disease (CD) are at increased risk of venous thromboembolism (VTE). It was surmised, but not conclusively shown that the risk is related to plasma hypercoagulability secondary to the effect of glucocorticoids. This study aimed at investigating the thrombin-forming potential of patients with CD in the presence of a functioning protein C system by adding its main physiological activator, thrombomodulin. Under these experimental conditions, which mimic close...